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We believe in providing the most comfortable, highest quality and performance uniforms for an array of people serving our country and communities today. Our goal is to stay ahead of the latest innovations in research, style and fabrics so that our customers experience the perfect fit, comfort and function the first time around. As a Berkshire Hathaway company, and with more than a century and a half of manufacturing uniforms, you can count on us to be with you now and in the future.
Daniela Fechheimer; Daniel Goldin; Daniel Goldin; Open Report Verified Name Match. Goldin New York, NY Locations Include: New York, NY. Fechheimer Brothers Company, began the journey of manufacturing the world’s most trusted uniforms for public safety in 1842. Solomon “Samuel” Fechheimer, a German immigrant, opened a small dry goods store in Cincinnati, OH. Samuel combined adventure and passion, seeking out opportunities to grow his business and give back through his trade. Fechheimer #TT151 Men's Pink Tan T-1 Gabardine 100% Visa® System 3 Polyester Trouser. $44.69 to $164.99 $ 26.99 to $164.99. Compare SALE. Fechheimer #TR633 Fechheimer Women's Deluxe Tactical Trousers. $83.99 $ 50.99. Compare SALE. Fechheimer #TJ167 WOMEN'S LEGEND POLY/WOOL TROUSER W/FLEX & INSIDE CARGO. $159.00 $ 83.99.
In addition to our desire to serve you, we are proud to be:
- The leading brand trusted by the U.S. Navy for dress uniforms.
- The preferred choice of such venerable public safety agencies such as the California Highway Patrol (CHP), LAPD and Cincinnati Police.
- The only uniform worn by world-renown transit authorities such as the MBTA and the San Francisco Municipal Transportation Agency and the Chicago Transit Authority.
Our resources are global with manufacturing partners in Central and South America, Europe, Africa and Asia to complement our three plants in Cincinnati, Ohio, Hodgenville, Kentucky, and Grantsville, Maryland in the United States.
We can meet most any need with the largest in-stock offerings available for law enforcement, fire, EMS, military and transportation professionals and our custom programs. Our high-quality uniforms are available to you through a network of more than 500 independent stores in over 51 countries worldwide and online.
Meigs Professor
Basic Information
The actin cytoskeleton makes primary contributions to the maintenance of cell shape, and the production of force for cell movements in eucaryotic cells. Alterations in the structure and function of the cytoskeleton are implicated in numerous diseases and conditions including aging, and neurodegenerative disease. Hirano bodies are actin rich inclusions associated with normal aging, and with Alzheimer's disease, but the dynamics and physiological function of Hirano bodies are poorly understood. Our laboratory has developed models for the study of the Hirano bodies in the social amoeba Dictyostelium, cultured mammalian cells, and a transgenic mouse Hirano body model. These models have enabled our studies of the cell biological mechanisms for the formation and the degradation of Hirano bodies, and for studies of the role of these inclusions in the progression of disease. Two current research areas are highlighted below:
Hirano bodies and Alzheimer's Disease Pathology
Alzheimer’s disease is a progressive neurodegenerative condition characterized by loss of synapses, loss of neurons, progressive cognitive decline, and loss of synaptic plasticity. These aspects of Alzheimer’s pathology can be investigated using transgenic mouse models of this disease. Crosses of our Hirano body mouse with Alzheimer’s disease model mice will allow study of the impact of Hirano bodies on the development of pathology, and loss of memory in these mouse models. Findings that Hirano bodies either significantly accelerate or impair the development of pathology would identify Hirano bodies are a novel pathway for development of therapeutics for the treatment of Alzheimer’s disease.
Association of AICD and Tau with Hirano bodies
The amyloid precursor protein and tau are the two proteins most firmly implicated in the pathology of Alzheimer’s disease. Both proteins have been localized to Hirano bodies in Alzheimer’s brain, and we have confirmed the localization of both proteins with our model Hirano bodies. We are investigating the isoforms of tau and the specific regions of APP that associate with Hirano bodies, the mechanism of these associations, and the physiological function. Results of an initial study show that Hirano bodies sequester the intracellular domain of APP (AICD), and modulate AICD dependent cell death and AICD dependent gene transcription. Studies of the effects of Hirano bodies on toxicity induced by other regions of APP and by tau are in progress.
Ha, S., Furukawa, R., Stramiello, M., Wagner, J.J., and Fechheimer, M. (2011). Transgenic Mouse Model for the Formation of Hirano Bodies. BMC Neurosci. 12:97. [Epub ahead of print]
Ha, S., Furukawa, R., and Fechheimer, M. (2011). Association of AICD and Fe65 with Hirano bodies reduces transcriptional activation and initiation of apoptosis. Neurobiol Aging. 32:2287-98.
Kim, D.-H., R. Furukawa, and M. Fechheimer. 2009. Degradation of Hirano Bodies by Autophagy5, 44-51.
A two letter code was used to designate month and year of manufacture. All Marlins manufactured from 1969 to 1990: The first two digits of the serial number designate the year of manufacture, either as the last two digits of the year (in 1969-71) or as a number code (1971 and later). Marlin model 60 serial number date of manufacture.
Davis, R. C., Furukawa, R., and M. Fechheimer, 2008. A Mammalian Cell Culture Model for the Formation of Hirano Bodies, Acta Neuropathologica115, 205-217.
Stich, R. W., G. A. Olah, K. A. Brayton, W. C. Brown, M. Fechheimer, K. Green-Church, S. Jittapalapong, K. M. Kocan, T. C. McGuire, F. R. Rurangirwa, and G. H. Palmer. 2004. Identification of a novel Anaplasma marginale appendage-associated protein that localizes with actin filaments during intraerythrocytic infection. Infection and Immunity72, 7257-7264.
Maselli, A., R. Furukawa, S. A. M. Thomson, R. C. Davis, and M. Fechheimer. 2003. Formation of Hirano Bodies Induced by Expression of an Actin Cross-linking Protein With a Gain of Function Mutation. Eucaryotic Cell2, 778-787.
Maselli, A. G., R. Davis, R. Furukawa, and M. Fechheimer. 2002. Formation of Hirano Bodies in Dictyostelium and Mammalian Cells Induced by Expression of a Modified form of an Actin Cross-linking Protein. J. Cell Science115, 1939-1952.
![Daniela Fechheimer Goldin Daniela Fechheimer Goldin](/uploads/1/1/7/8/117884417/785010808.jpg)
Lim, R. W. L., R. Furukawa, and M. Fechheimer. 1999. Evidence of Intramolecular Regulation of the Dictyostelium discoideum 34,000 dalton F-actin Bundling Protein. Biochemistry38, 16323-16332.
Lim, R. W. L., R. Furukawa, S. Eagle, R. C. Cartwright, and M. Fechheimer. 1999. Three Distinct F-actin Binding Sites in the Dictyostelium discoideum calcium-regulated 34,000 dalton Actin Bundling Proten. Biochemistry38, 800-812.
Daniela Fechheimer Goldin Md
Rivero, F., R. Furukawa, M. Fechheimer, and A. A. Noegel. 1999. Three actin cross-linking proteins, the 34 kDa actin-bundling protein, a-actinin, and ABP-120, have both unique and redundant roles in the growth and development of Dictyostelium.J. Cell Science112, 2737-2751.
Clem, R. J., M. Fechheimer, and L. K. Miller. 1991. A Baculovirus Gene Required to Prevent Apoptosis During Infection of Insect Cells. Science254, 1388-1390.
Daniela Fechheimer Goldin New York
Fechheimer, M., and J. J. Cebra. 1982. Phosphorylation of Lymphocyte Myosin Catalyzed In Vitro and In Intact Cells. J. Cell Biol.93, 261-268.